I am only allowed to pack a suitcase for the trip home.
I don't have the "packing gene" and even if I roll, tissue, layer, dry cleaner bag and all the other tricks, I still end up with wrinkles clothes. I pack the hardware but clothes are for my wife to pack.
One thing to keep in mind is that when you buy the "biggest" suitcase you are usually buying the heaviest. Don't waste your 50 lbs. with a 22 lb. suitcase. Often a smaller, lighter weight, suitcase will allow you to pack more.