It seems there are many itineraries that depart from Barcelona or Southampton that don't go east of Venice - though you are really missing out if you don't.
Also, Costa has routes that navigate around Italy if that is your focus.
All I ask is a tall ship and a star to steer her by; John Masefield
Carnival: Glory 2004, Destiny 2008, Splendor 2009, Freedom 2011, Valor 2012, Dream 2013
Celebrity: Summit 2011
Princess: Ruby 2010, 2014, Caribbean 2013, Coral 2014, Regal 2014
Star Clippers: Royal Clipper 2015