I mostly do transatlantic crossings, though soon I will want to a Med cruise. Americans really get good deals from Cunard (I so much want to try it) in April there was a crossing on QM2 for just over $1500 ($750pp) for 2, which was a blacony cabin with onboard credit. Most of my experience has been with RCCL, however I have done several others: Celebrity, MSC, Disney and Carnival.
While it has been fun over the last 10 cruises, it would be nice to travel with a like minded traveler. We are the same, me 40 so perhaps it could work.