Hi Brittany,
We did a trip to Tampa and Busch Gardens years ago and thought it was well worth the traveling from Orlando, you can get only so much Disney, needed a change and it was a welcome visit. We stayed at a Holiday in right on the beach in Tampa along the strip there. Of course we had already done Epcot, which I sure wouldn't want to miss either, so its really up to you, if you feel like driving to Tampa and Busch Gardens. Either way, you'll have a great time.
Donnassei