Placing your meds in your checked baggage is asking for trouble in more ways than one. It risks you losing the medications in the event your luggage is lost, damaged or a dishonest person gets their hands on it. It also puts your prescription medication at risk in the unlikely event it is confiscated. Controlled substances such as narcotics or sedatives should always travel with the person to whom they are prescribed.
I believe that if the medication is important enough for you to have a prescription for it and you have brought it with you on vacation, it is important enough to stay with you. Keep it in your carryon bag.