I have never been on a Nile River cruise myself, however one of my friends did and loved it. She has some health concerns but didn't get sick from the food. Since she doesn't have children, though, I can't give you feedback in that area. I'll ask around to the other CruiseMates.com editors and see if any of them have been on a Nile Cruise. As for safety, it seems like it's been relatively quiet as far as any incidents relating to tourists in Egypt. However, you should check with the State Dept. in D.C. to make sure there aren't any travel advisories out for Americans traveling to Egypt.
I'll let you know if I get some feedback from others about the Nile Cruise.