I too get motion sick. Never took anything while on board. Felt it a little when aft or foreward but other than that never had any problem when on the AK cruise (now Virgin Island Cruise in January!!! yes then you better take something). I did take 2 Dramamine non-drowsy when I got on the helicopter & the float plane because I wasn't sure & didn't want to ruin my trip. Worked great (took 1 hr before) & never got drowsy - mellow but not drowsy (maybe the mellow was just the serene beautiful scenery however.