If you're stopping in Ketchikan, then book a seaplane tour for the Misty Fjords. Must see. But leave enough time for you and your wife to walk the streets. Great houses with lots of character. Also, Creet Street is the old red light district. Really cool picture taking opportunities there.
www.ketchikanblog.com is a good site for inquiring tourists.
~Allison
Ketchikan resident