Where do you live? Is one port closer to you than the other? We are sailing the Ecstasy in March out of Galveston because we live near there and wont need the airfare! Also will you be doing any pre or post cruise sightseeing at home port?
I can't speak about what you should do but we are doing the Sensation out of New Orleans in December. We chose New Orleans as we are staying a couple of days after the cruise and there is so much to do there. I'm sure you'll have a great time either way.