Used Priceline once and was pleased. I prefer Hotwire, though, because you see the star rating and price ahead of time. Many times you can get a higher star rating for a cheaper price than a lower quality hotel.
I use Hotwire all the time and have never been disppointed and usually find the rates 40-50 percent below those advertised on Travelocity, for instance.
I just recently used Priceline for the first time. I did get a hotel where I wanted to be, but was hoping for a different one, but for the price, I did well and don't see any problem. Just make sure you have the location right, good luck.
I used Priceline, picked a 3 star hotel, downtown Miami, bid $40. I got the Marriott Bayside for the $40 plus about $12 service and taxes, total cost $52 a night. This hotel normally goes for around $200. You decide wether or not you want to try Priceline.
Costa Atlantica, 3/23/03
Jewel, 2/1/10, RCI cancelled our cruise, (insert sound of sobbing)
I would highly recommend using the biddingfortravel website, then you can see which hotels are being received and what the prices are. One of the keys is understanding the concept of a "free zone" rebid.
We have used priceline for hotels several times and have never had any problems. We got the Hyatt in Miami for $35 last year, and got a great room on the corner of the hotel.
I used priceline for 5 rooms in downtown miami. Got three at Doubletree Biscayne and two at Hyatt Regency for $40 each plus a few dollars each room for fees. Both hotels were excellent and convenient to the port of Miami. Would use priceline if you don't need a specific hotel.