While I have not stayed here in years, it is my favorite Lauderdale hotel.
Right up the street there is the Southport Shopping Center:
Shopping Center, located close to the Fort Lauderdale Beach and Port Everglades, boasts over 48 specialty shops and restaurants, including: Publix, a local grocery store chain; Carriage Clothiers, Ltd., an upscale men's clothing store; and Nature's Remedy, a health food store and juice bar. It's a great "one stop shopping" center where you can purchase a variety of items including groceries, clothing, accessories, gifts and of course, Florida souvenirs.
I checked the water taxi site...and it does not pickup at Pier 66
The Walgreens and the Ren Hotel, is not a terrible walk from the hotel.
Honestly I don't remember seeing trolleys on the A1A...