There are lots of departure options for you -- in FLorida (Port Canaveral, Miami, Ft. Lauderdale, Tampa and Jacksonville) as well as seasonal departures from a number of Southern ports. If you're looking to depart from the south other than Florida, see what Carnival and Norwegian Cruise Line have to offer -- they seem to be the leaders in offering many options of domestic embarkation ports. They also have good kids' programs and family friendly facilities.
Luisa Frey Gaynor
Family Cruise Editor