i think that packing your "cruise clothes" separate is a great idea.
Weigh your bags to make sure that you are not over the airlines weight limit.
2 smaller bags are easier to lug around that 1 big one -IMO
Plan on doing some laundry on the cruise so that you don't have to pack as much.
Mix and match your pre and post-cruise clothes- who cares if you wear the same outfit pre and post cruise as long as its neat & clean
Definatley put all meds, jewlery, documents, camera's etc in the carry-on.
Use skycaps, bellhops and porters whenever possible.